Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants

This research, conducted by Church et al. (2018), explores how micronutrient deficiencies might contribute to reduced oral vaccine immunogenicity in Zimbabwean infants and how vitamin A supplements may influence this process. The work was published in Transactions of The Royal Society of Tropical Medicine and Hygiene. A cross-sectional study of 181 infants recruited at birth to the Zimbabwe Vitamin A for Mothers and Babies (ZVITAMBO) trial in Zimbawe (1197 – 2001) was carried out and poliovirus-specific IgA to type 1–3 polio strains was measured. Their results showed no significant effect of neonatal vitamin A supplements augmenting oral polio vaccine responses in Zimbabwean infants.